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Green treefrogs, like most other treefrogs, should be handled as little as possible. Their skin is semi-permeable and easily torn, and it is highly sensitive to chemical toxicity, found in things such as perfume, cologne, or nail polish. Also, if your frog is sitting in your palm, his blood temperature will rise quickly, and temperature fluctuations can be dangerous to his health. If at all possible, reserve the handling of your treefrog for important situations like moving him between terrariums or inspecting him for health problems. The rest of the time, you should observe your green treefrog with a layer of glass between the two of you.
For more information, read Quick & Easy Green Treefrog Care (T.F.H. Publications, Inc.).