There are certain precautions that should be taken when handling a red-eared slider. As a general rule, you should try to only handle your turtle when absolutely necessary, such as when taking him to the vet or moving him to a new enclosure. While some red-eared slider don't seem to mind being picked up and handled, it is generally safer for your pet to be kept in his cage. You should always wash your hands before and after any kind of physical contact with your turtle. Reptiles, including red-eared sliders, have been associated with the transmission of certain diseases, so make it a habit to thoroughly clean your hands.